Abstract
Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / metabolism
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Cell Membrane / drug effects
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Cell Membrane / metabolism
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Dronabinol / analogs & derivatives*
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Dronabinol / chemical synthesis
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Dronabinol / chemistry
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Dronabinol / metabolism
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Mice
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Rats
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Receptor, Cannabinoid, CB2*
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Receptors, Cannabinoid
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Receptors, Drug / drug effects
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Receptors, Drug / metabolism
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Spleen / metabolism
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Structure-Activity Relationship
Substances
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Cnr2 protein, rat
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Receptor, Cannabinoid, CB2
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Receptors, Cannabinoid
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Receptors, Drug
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delta-8-tetrahydrocannabinol
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Dronabinol